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Updated: Feb 13, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Genomic sequences of HLA-A*68:169, HLA-B*07:298 and HLA-B*39:129
A Balas1, D Planelles2, M Rodríguez-Cebriá2
1Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spain.
Abstract:
Three new HLA class I alleles were described in the Spanish population. HLA-A*68:169 and -B*39:129 show one amino acid replacement at the α1-domain, compared to A*68:02 (P47 > L47) and -B*39:06 (S11 > A11), respectively. HLA-B*07:298 presents one nucleotide mutation within exon 1, resulting in a new amino acid position -14, L>Q, which has not been previously described in any HLA protein. Prediction of the B*07:298 signal peptide cleavage did not show significant differences in comparison with that obtained for the rest of HLA-B genes.
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