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Hepatic Adenoma Arising in a Patient With Alagille Syndrome: A Case Report
M Cristina Pacheco1,2, Eric J Monroe3,4, Simon P Horslen5,6
11 Department of Pathology, University of Washington, Seattle, Washington.
Abstract:
Alagille syndrome is associated with decreased bile ducts, cardiac abnormalities, vertebral body fusion defects, and a typical facies. While regenerative nodules and hepatocellular carcinoma have been described in these patients, hepatic adenoma has not. Herein, we present a patient with Alagille syndrome caused by a mutation in NOTCH2 with a hepatic adenoma. The clinical, imaging, and histologic features are discussed.
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