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Mechanisms correlated with chemotherapy resistance in tongue cancers

Guanghong Han1, Chengbi Xu2, Dan Yu2

  • 1Department of Oral Geriatrics, School and Hospital of Stomatology, Jilin University, Changchun 130021, China.

Journal of Cancer Research and Therapeutics
|March 9, 2018
PubMed

Insights

Tongue cancer drug resistance hinders treatment outcomes. This review summarizes key proteins, biomacromolecules, and pathways involved, aiding researchers in developing new therapeutic strategies for this deadly head and neck cancer.

Area of Science:

  • Oncology
  • Head and Neck Cancer Research
  • Molecular Biology

Background:

  • Tongue cancer is a prevalent and lethal head and neck malignancy.
  • Increasing incidence rates are observed globally.
  • Poor prognosis is often linked to chemotherapy resistance, with unclear underlying mechanisms.

Purpose of the Study:

  • To review recent literature on tongue cancer drug resistance.
  • To identify proteins, biomacromolecules, and signaling pathways implicated in this resistance.
  • To provide a reference for developing novel treatment strategies.

Main Methods:

  • Comprehensive literature search of recent publications.
  • Systematic review and synthesis of findings related to drug resistance mechanisms.
  • Identification and categorization of molecular targets.

Main Results:

  • Several key proteins and biomacromolecules identified as crucial in tongue cancer drug resistance.
  • Specific signaling pathways implicated in mediating chemotherapy resistance elucidated.
  • A consolidated overview of molecular factors contributing to treatment failure.

Conclusions:

  • Understanding the molecular basis of tongue cancer drug resistance is critical.
  • The identified targets offer potential for developing more effective therapies.
  • Further research into these mechanisms can improve clinical outcomes for tongue cancer patients.
Keywords:
Resistancetongue cancertreatment

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