Synthesis, molecular modeling and evaluation of α-glucosidase inhibition activity of 3,4-dihydroxy piperidines
Siva Prasad Kasturi1, Sujatha Surarapu2, Srinivas Uppalanchi2
1Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd, Plot.No.28 A, IDA, Nacharam, Hyderabad 500076, Telangana State, India; Centre for Chemical Sciences & Technology, Institute of Science and Technology, JNTUH, Kukatpally, Hyderabad 500085, Telangana State, India.
Abstract:
Biological evaluation of 3,4-dihydroxy piperidines as α-glucosidase inhibitors is being reported for the first time. Forty-five derivatives (amides, di-amides and sulfonamides) were made using cis and trans 3,4-dihydroxy piperidines to evaluate their α-glucosidase inhibition activity. Polar groups (-OH, -NH2) on phenyl ring having derivatives 5i, 5l, 7g, 7i &12j showed excellent activity compared to standard references. Acarbose, Voglibose and Miglitol were used as standard references. Molecular docking simulations were done for compounds to identify important binding modes responsible for inhibition activity of α-glucosidase.
More Related Videos
06:55Developing a Behavioral Box for Assessing Prepulse Inhibition and Neural Activity in Psychiatric Animal Models
Published on: July 22, 2025
13:38Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
Related Concept Videos
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Molecular Models
Inhibition of Cdk Activity
Feedback Inhibition
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Self-Evaluation Maintenance Model
