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Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Matheus Aparecido Dos Santos Ramos1, Patrícia Bento Da Silva2, Larissa Spósito1

  • 1São Paulo State University (UNESP), School of Pharmaceutical Sciences, Campus Araraquara, Department of Biological Sciences, Araraquara, SP, Brazil.

International Journal of Nanomedicine
|March 10, 2018
PubMed

Insights

New nanotechnology approaches combat drug-resistant microbial biofilms. This study explores nanoparticles like liposomes and metallic nanoparticles for targeted drug delivery, enhancing anti-biofilm therapies.

Area of Science:

  • Microbiology and Nanotechnology

Background:

  • Pathogenic microorganisms cause fatal infections, with biofilms exacerbating chronic conditions and drug resistance.
  • Biofilm elimination is challenging due to inherent microbial resistance to conventional antimicrobial drugs.
  • Developing novel anti-biofilm strategies is crucial for effective infection control.

Purpose of the Study:

  • To investigate the application of nanotechnology for targeted drug delivery against microbial biofilms.
  • To explore the potential of various nanoparticles in enhancing the efficacy of anti-biofilm agents.
  • To understand the role of nanosystems in controlling biofilm-associated infections.

Main Methods:

  • Utilized various nanoparticles, including liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles.
  • Employed targeted drug delivery systems for enhanced anti-biofilm activity.
  • Evaluated the efficacy of these nanosystems in controlling microbial biofilms.

Main Results:

  • Demonstrated the effectiveness of diverse nanoparticles in controlling microbial biofilms.
  • Showcased the enhanced bioactive potential of therapeutic agents via nanotechnology-based drug delivery.
  • Provided insights into the application of nanosystems for combating biofilm infections.

Conclusions:

  • Nanotechnology offers promising platforms for targeted drug delivery to combat microbial biofilms.
  • Nanosystems significantly enhance the therapeutic potential of agents used against biofilms.
  • Further research into these nanosystems is vital for developing advanced anti-biofilm treatments.
Keywords:
anti-biofilm activitymicrobial biofilmsnanotechnology systems

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