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Updated: Feb 13, 2026

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Published on: July 31, 2021
Separating the coherence transfer from chemical shift evolution in high-resolution pure shift COSY NMR
Juan A Aguilar1, Raquel Belda1, Benjamin R Gaunt1
1Department of Chemistry, University of Durham, Durham, UK.
Advanced NMR techniques now offer high-resolution 2D spectra for small molecules. This study explores challenges in applying these to COSY spectra and proposes a solution for improved peak dispersion.
Area of Science:
- Nuclear Magnetic Resonance (NMR) Spectroscopy
- Analytical Chemistry
- Organic Chemistry
Background:
- Recent advancements in data sampling and processing enable high-resolution 2D NMR spectra.
- These techniques improve effective resolution (peak dispersion) and address peak overlap issues.
- Successful applications demonstrated for TOCSY and HSQC experiments.
Purpose of the Study:
- To investigate challenges in applying advanced high-resolution 2D NMR techniques to COSY spectra.
- To propose a modification to the classic COSY experiment to overcome these challenges.
Main Methods:
- Exploration of limitations in current high-resolution 2D NMR for COSY.
- Development and suggestion of a modified COSY pulse sequence.
Main Results:
- Identified specific problems in applying advanced sampling and processing to COSY.
- Proposed a modified COSY experiment designed to alleviate these identified issues.
Conclusions:
- Advanced 2D NMR techniques show promise for small molecule analysis.
- A modified COSY experiment is suggested to enhance spectral resolution and reduce peak overlap.
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