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The effect of hemodialysis on intraocular pressure

Ayse Ebru Bahadir Kilavuzoglu1, Gurkan Yurteri2, Nurgul Guven3

  • 1Department of Ophthalmology, Acibadem University School of Medicine, Istanbul, Turkey.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|March 10, 2018
PubMed

Insights

Hemodialysis (HD) significantly reduces intraocular pressure (IOP) in patients with end-stage renal disease. This study observed a decrease in IOP during HD, correlating with changes in serum osmolality and blood urea nitrogen.

Area of Science:

  • Nephrology
  • Ophthalmology
  • Clinical Medicine

Background:

  • The impact of hemodialysis (HD) on intraocular pressure (IOP) lacks consistent findings, yet is crucial for managing glaucoma patients with renal failure.
  • Understanding HD's effects on IOP is vital for clinicians overseeing renal failure patients.

Purpose of the Study:

  • To investigate the effects of hemodialysis on intraocular pressure (IOP) in patients diagnosed with end-stage renal disease.

Main Methods:

  • A prospective study involving 106 patients undergoing outpatient hemodialysis.
  • Measurements included serum osmolality, blood urea nitrogen, blood glucose, bicarbonate, hematocrit, blood pressure, and IOP at various stages of HD.
  • Patient medical and ophthalmologic histories were documented.

Main Results:

  • Intraocular pressure (IOP) showed a significant decrease from pre-HD (16.71 ±2.51 mm Hg) to end-HD (15.52 ±3.18 mm Hg) and post-HD (15.23 ±2.73 mm Hg).
  • Hemodialysis led to significant changes in serum osmolality, blood urea nitrogen, blood glucose, bicarbonate, and hematocrit levels.
  • A positive correlation was found between the change in IOP and the changes in serum osmolality and blood urea nitrogen at the end of HD.

Conclusions:

  • Intraocular pressure (IOP) significantly decreases during hemodialysis.
  • Further research is recommended to explore how blood parameter changes and ocular perfusion pressure influence IOP and optic nerve perfusion during HD.
Abstract

Keywords:
glaucomahemodialysisintraocular pressure

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