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[Personalised medicine for psychosis]
Tijdschrift Voor Psychiatrie
|March 10, 2018
Summary
Personalised medicine (pm) is not yet viable for psychotic disorders using genetics alone. Current pm in psychosis focuses on phenotypic, cognitive, and psychosocial factors.
Area of Science:
- Psychiatry
- Pharmacogenomics
- Personalised Medicine
Background:
- Personalised medicine (pm) tailors treatments based on individual patient characteristics.
- Current application of pm in psychotic disorders is limited by the sensitivity and specificity of genetic and biological markers.
- Phenotypic, cognitive, and psychosocial factors are currently utilized for pm in psychosis.
Purpose of the Study:
- To provide an updated review of the current use of personalised medicine in the treatment of psychotic disorders.
Main Methods:
- Literature review on personalised medicine approaches for psychosis.
Main Results:
- Genetic and biological markers lack sufficient sensitivity and specificity for current diagnosis and treatment in psychotic disorders.
- Investigated immunological, oxidative, metabolic, hormonal, and dopaminergic aspects for potential pm applications.
- Personalised medicine is currently applied using phenotypic, cognitive, and psychosocial characteristics such as substance abuse, cognitive dysfunction, ethnicity, and childhood trauma.
Conclusions:
- Future opportunities for personalised medicine in psychosis are expected to increase.
- Advancements may stem from large genetic network studies and stratified treatment studies focusing on specific mechanisms rather than broad diagnostic categories like schizophrenia.
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