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Updated: Feb 13, 2026

Transurethral Induction of Mouse Urinary Tract Infection
Published on: August 5, 2010
Impact of an antimicrobial stewardship program on urinary tract infections caused by extended-spectrum
E Esteve-Palau, S Grau1, S Herrera
1Santiago Grau. Service of Pharmacy. Hospital del Mar. Passeig Marítim 25-29, 08003 Barcelona, Spain. sgrau@parcdesalutmar.cat.
Objective:
To analyze the clinical and economic impact of an antimicrobial stewardship program (ASP) targeting urinary tract infections (UTI) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli.
Methods:
An observational retrospective study that included adults with a diagnosis of UTI caused by ESBL-producing E. coli admitted to a tertiary care hospital in Barcelona, Spain, between January 2014 and December 2015. The impact of the ASP was analyzed in terms of clinical and economic outcomes.
Results:
A total of 222 patients met the inclusion criteria and an intervention was made by the ASP team in 104 cases (47%). ASP intervention was an independent variable related to clinical cure (p = 0.008). Other variables influencing clinical outcomes were the McCabe Jackson score (p = 0.005) and outpatient status (p < 0.001). The ASP interventions in this study had no economic impact.
Conclusions:
Antimicrobial stewardship has a positive clinical impact on UTIs caused by ESBL-producing E. coli. Further prospective studies are needed to assess the economic impact of ASPs on UTI caused by ESBL-producing E. coli.
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Urinary Tract Infection II: Pathophysiology
Urinary Tract Infection IV: Nursing Management
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
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Urinary Tract Calculi V: Nursing Management

