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Predicting mortality in patients with spontaneous bacterial peritonitis using routine inflammatory and biochemical
Raim Iliaz1, Tahsin Ozpolat2, Bulent Baran3
1Department of Gastroenterology, Istanbul School of Medicine, Istanbul University.
European Journal of Gastroenterology & Hepatology
|March 10, 2018
Summary
Spontaneous bacterial peritonitis (SBP) in cirrhosis patients has high 30-day mortality. Inflammatory markers and Model for End-Stage Liver Disease (MELD) scores can predict mortality in SBP patients.
Area of Science:
- Hepatology
- Infectious Diseases
- Critical Care Medicine
Background:
- Spontaneous bacterial peritonitis (SBP) is a frequent and lethal infectious complication in patients with cirrhosis.
- Identifying predictors of mortality is crucial for managing SBP.
Purpose of the Study:
- To determine the 30-day mortality rate of SBP.
- To identify predictors of 30-day mortality in SBP patients.
Main Methods:
- A study enrolled 70 patients with cirrhosis and SBP and 55 controls.
- Mortality rates and predictors were evaluated, including inflammatory markers and Model for End-Stage Liver Disease (MELD) scores.
Main Results:
- 30-day mortality for SBP was 26.1%, with higher rates than controls.
- High serum neutrophil counts, neutrophil-lymphocyte ratio, C-reactive protein (CRP)/albumin ratio, and MELD scores predicted higher 30-day mortality.
- Optimal MELD score cutoff was 20.5 (83.3% sensitivity, 80.4% specificity).
Conclusions:
- SBP is associated with significant 30-day mortality.
- MELD scores and inflammatory markers (CRP, CRP/albumin ratio, neutrophil-lymphocyte ratio) are valuable predictors of mortality in SBP.
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