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Protein Glycosylation01:25

Protein Glycosylation

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Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
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C4 Pathway and CAM01:27

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Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
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Other Glycolytic Pathways01:24

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The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
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Respiration Pathways01:26

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Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...
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Auditory Pathway01:15

Auditory Pathway

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Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
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ER Retrieval Pathway01:45

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In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
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Related Experiment Video

Updated: Feb 13, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

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Glycosylation pathways at the ocular surface.

Maria C Rodriguez Benavente1, Pablo Argüeso2

  • 1Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, U.S.A.

Biochemical Society Transactions
|March 11, 2018
PubMed
Summary
This summary is machine-generated.

Glycosylation, a key biological process, involves enzymes that create diverse sugar structures. Understanding ocular surface glycosylation pathways can reveal new therapeutic targets and biomarkers.

Keywords:
biosynthetic pathwaysglycosylationocular surface

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Area of Science:

  • Biochemistry
  • Glycobiology
  • Ocular Surface Science

Background:

  • Glycosylation is a critical enzymatic modification essential for numerous biological processes.
  • The ocular surface features complex glycosylation patterns, including mucin-type O-glycans and N-glycans.
  • While some glycosylation pathways are known, many remain uncharacterized.

Purpose of the Study:

  • To review known glycan classes at the ocular surface.
  • To focus on the biosynthetic pathways and biological relevance of these glycans.
  • To highlight the importance of understanding glycosylation in ocular health and disease.

Main Methods:

  • Literature review of glycosylation pathways at the ocular surface.
  • Analysis of biosynthesis of O-glycans and N-glycans.
  • Discussion of biological relevance and potential therapeutic applications.

Main Results:

  • Overview of diverse glycan structures and their biosynthesis at the ocular surface.
  • Identification of known and unknown glycosylation pathways.
  • Emphasis on the role of glycosyltransferases, glycosidases, and glycan-modifying enzymes.

Conclusions:

  • A comprehensive understanding of ocular surface glycosylation is crucial.
  • Knowledge of these pathways can lead to the identification of novel biomarkers.
  • Targeting glycosylation pathways offers potential for therapeutic interventions in ocular diseases.