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Updated: Feb 13, 2026

An Aptamer-based Sensor for Unchelated GadoliniumIII
Published on: January 9, 2017
A Review of the Current Evidence on Gadolinium Deposition in the Brain
Richard Pullicino1, Mark Radon2, Shubhabrata Biswas2
1Neuroradiology Department, The Walton Centre NHS Foundation Trust, Lower Lane, L9 7LJ, Liverpool, UK. richard.pullicino@gmail.com.
Abstract:
Over the past 3 years, gadolinium-based contrast agents have been linked to MRI signal changes in the brain, which have been found to be secondary to gadolinium deposition in the brain, particularly in the dentate nuclei and globus pallidus even in patients having an intact blood-brain barrier and a normal renal function. This tends to occur more in linear agents than with macrocyclic agents. Nonetheless, there has been no significant evidence that this has any clinical consequence. We reviewed the current evidence related to this new phenomenon and the precautionary approach taken by regulatory agencies.
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