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Related Experiment Video

Updated: Feb 13, 2026

A Nonsequencing Approach for the Rapid Detection of RNA Editing

A Nonsequencing Approach for the Rapid Detection of RNA Editing

Published on: April 21, 2022

Neuroepigenetic Editing.

Peter J Hamilton¹, Carissa J Lim², Eric J Nestler¹

¹The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA.

Methods in Molecular Biology (Clifton, N.J.)

|March 11, 2018

Summary

This summary is machine-generated.

Neuroepigenetic editing tools are emerging to understand gene expression in the nervous system. These methods help determine the functional relevance of epigenetic modifications in neural transcription and behavior.

Keywords:

Chromatin Epigenetic editing Neuroscience Psychiatric disease

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Area of Science:

Neuroscience
Epigenetics
Molecular Biology

Background:

Epigenetic regulation is crucial for nervous system function and neurological diseases.
Neural regulation of chromatin-modifying enzymes plays a key role in development, adulthood, and response to stimuli.
Next-generation sequencing (NGS) studies quantify epigenetic modifications in neurons.

Purpose of the Study:

To review advances in neuroepigenetic editing tools.
To highlight methodological considerations for neuroscience applications.
To discuss the potential of neuroepigenetic editing for research and therapeutics.

Main Methods:

Application of neuroepigenetic editing tools.
Analysis of epigenetic modifications in neurons.
Assessment of neural transcription and animal behavior.

Main Results:

Neuroepigenetic editing can distinguish the functional relevance of epigenetic modifications.
Methodological considerations include delivery methods and spatiotemporal specificity.
The field is nascent but shows significant potential.

Conclusions:

Neuroepigenetic editing offers powerful approaches for basic neurobiological research.
This technology holds promise for developing therapeutic applications for neurological disorders.
Further development is needed to optimize delivery and specificity for broader application.