Related Experiment Video
Updated: Feb 13, 2026
06:12
Author Spotlight: Optimizing Bovine Lung Decellularization for Organotypic Hydrogels
Published on: December 8, 2023
2.3K
Extracellular matrix in lung development, homeostasis and disease
Yong Zhou1, Jeffrey C Horowitz2, Alexandra Naba3
1Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, United States.
Summary
The lung
Area of Science:
- Pulmonary Biology and Regenerative Medicine
Background:
- The lung's extracellular matrix (ECM) provides structural support and regulates cell functions, fate, and phenotype.
- Dysfunctional lung ECM is implicated in pathological tissue remodeling and chronic lung diseases.
Purpose of the Study:
- To review current advancements in lung ECM biology.
- To explore ECM's role in lung development, disease, and stem cell regulation.
- To identify research priorities for novel therapeutic strategies.
Main Methods:
- Comprehensive literature review of lung ECM biology.
- Analysis of ECM's role in normal and aberrant lung development.
- Assessment of ECM in adult lung diseases, autoimmunity, and stem cell niches.
Main Results:
- Lung ECM composition, dynamics, topography, and biomechanics are crucial for lung health.
- ECM plays a significant role in lung development, disease pathogenesis, and stem cell niche regulation.
- ECM-based therapeutics and bioengineering offer promising avenues for lung regeneration and treatment.
Conclusions:
- Understanding lung ECM biology is vital for developing new treatments for chronic lung diseases.
- Further research into lung ECM is recommended to inform novel diagnostic and therapeutic approaches.
Related Concept Videos
01:42The Extracellular Matrix
89.5K
Overview
89.5K
01:29The Extracellular Matrix
12.5K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.5K
01:26Extracellular Matrix
5.6K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.6K
01:16What is Homeostasis?
57.4K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
57.4K
01:31pH Homeostasis
20.1K
Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
Respiratory...
20.1K
01:21Skeleton and Calcium Homeostasis
6.1K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
6.1K