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Towards Understanding MCR-like Colistin Resistance
Jian Sun1, Huimin Zhang2, Ya-Hong Liu3
1National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou 510642, China; These authors contributed equally to this work.
Trends in Microbiology
|March 12, 2018
Summary
Antibiotic resistance is a global threat. New mobilized colistin resistance (mcr) genes challenge last-resort polymyxin antibiotics, necessitating further research into their epidemiology and resistance mechanisms.
Area of Science:
- Microbiology
- Molecular Biology
- Public Health
Background:
- Antibiotic resistance, particularly Gram-negative pan-drug resistance, is a critical global health concern.
- Polymyxins serve as a crucial last-resort antibiotic class for treating multidrug-resistant Gram-negative infections.
- The emergence and spread of mobilized colistin resistance determinants (mcr) pose a significant threat to the efficacy of polymyxins.
Purpose of the Study:
- To provide an updated overview of MCR-like colistin resistance.
- To consolidate current understanding of the molecular epidemiology and resistance mechanisms associated with MCR-like genes.
Main Methods:
- Review of existing studies on MCR-like colistin resistance.
- Analysis of molecular epidemiology data.
- Examination of resistance mechanisms.
Main Results:
- MCR-like genes represent a growing challenge to polymyxin effectiveness.
- Current research offers a foundational understanding of MCR-like gene epidemiology and mechanisms.
- The spread of these resistance determinants is a significant global concern.
Conclusions:
- Existing studies provide a framework for understanding MCR-like colistin resistance.
- Further large-scale epidemiological and functional studies are essential.
- Enhanced research is crucial for addressing this clinically important antibiotic resistance.
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