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Updated: Oct 17, 2025

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation

Weixiang Bian1, Mengfan Tang2, Hua Jiang1

  • 1Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, Zhejiang, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, Zhejiang, China; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou 310024, Zhejiang, China.

Developmental Cell
|October 9, 2021
PubMed
Summary

Researchers identified low-density-lipoprotein-receptor-related protein 1 (LRP1) as a key regulator of the Notch signaling pathway. LRP1 inhibition reduced cancer growth in leukemia models, suggesting its potential as a therapeutic target.

Keywords:
DLL3LRP1Notch pathwayinteraction networkleukemia

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