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Updated: Feb 13, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
[Management of drug-resistant epilepsy]
Marine Loizon1, Sylvain Rheims2
1Hospices civils de Lyon et université de Lyon, service de neurologie fonctionnelle et épileptologie, Lyon, France.
Abstract:
Epilepsy is considered as drug-resistant when seizures persist despite the administration of 2 antiepileptic drugs adapted to the patient's needs, with an effective dosage, well-tolerated, whether as a single agent or in combination. Any patient suffering from drug-resistant focal epilepsy should be evaluated at least once in a tertiary epilepsy centre to discuss the appropriateness of a pre-surgical work-up. In drug-resistant epilepsy, the determinants of quality of life are multifactorial and not exclusively linked to the seizure frequency. Anticipating the side effects of treatments is a key element during management of polytherapy. Screening for psychiatric and cognitive comorbidities must be systematic.
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