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Mild Cognitive Impairment in Parkinson's Disease-What Is It?

Rimona S Weil1,2, Alyssa A Costantini2, Anette E Schrag3,4

  • 1Dementia Research Centre, UCL, London, UK.

Current Neurology and Neuroscience Reports
|March 12, 2018
PubMed
Abstract

Insights

Mild cognitive impairment is common in Parkinson's disease, affecting cognition early. Understanding its progression and pathology may enable early interventions for Parkinson's disease dementia.

Area of Science:

  • Neurology
  • Neuroscience
  • Cognitive Science

Background:

  • Mild cognitive impairment (MCI) is a frequent characteristic of Parkinson's disease (PD), observable even in early stages.
  • Cognitive deficits in PD exhibit variability in type and severity, influencing the risk of developing Parkinson's disease dementia (PDD).

Purpose of the Study:

  • To review the current knowledge on mild cognitive impairment in Parkinson's disease.
  • To examine the presentation, conversion rates to dementia, pathophysiology, and potential biomarkers of MCI in PD.

Main Methods:

  • Literature review of recent large-scale longitudinal studies.
  • Analysis of current diagnostic criteria for MCI in Parkinson's disease.
  • Discussion of challenges and controversies surrounding MCI in PD.

Main Results:

  • Cognitive impairment is a significant and early feature of Parkinson's disease.
  • Recent criteria facilitate the study of cognitive decline, phenotypes, and dementia conversion risk.
  • Understanding MCI pathology and progression is key for early intervention.

Conclusions:

  • Mild cognitive impairment is integral to Parkinson's disease progression.
  • Further research into MCI in PD is crucial for developing timely therapeutic strategies.
  • Early identification and intervention for MCI may alter the course of Parkinson's disease and prevent dementia.
Keywords:
DementiaMild cognitive impairmentParkinson’s disease

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