Related Experiment Video

Updated: Feb 13, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

19.0K

[Research Advances of Pan-negative Type of Non-small Cell Lung Cancer]

Li Sun1, Zhicheng Xiong1, Chengbo Han1

  • 1Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|March 13, 2018
PubMed

Insights

Pan-negative lung cancer lacks known driver gene variations, unlike NSCLC with identified targets like EGFR or ALK. This review covers pan-negative NSCLC characteristics, epidemiology, treatment, and prognosis.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Advancements in molecular detection have identified numerous driver genes (e.g., EGFR, KRAS, BRAF) in non-small cell lung cancer (NSCLC).
  • Targeted therapies offer significant benefits to NSCLC patients with specific driver gene alterations.
  • A subset of NSCLC patients, termed pan-negative lung cancer, lacks these known driver gene variations.

Purpose of the Study:

  • To define and characterize pan-negative lung cancer.
  • To review the clinical and pathological features of pan-negative NSCLC.
  • To summarize the epidemiology, treatment strategies, and prognostic factors for pan-negative NSCLC.

Main Methods:

  • Literature review and synthesis of existing research on pan-negative NSCLC.
  • Analysis of clinical and pathological data from relevant studies.
  • Examination of epidemiological data and treatment outcomes.

Main Results:

  • Pan-negative NSCLC represents a distinct subgroup of non-small cell lung cancer.
  • Understanding its unique characteristics is crucial for effective management.
  • Current research is expanding to identify potential therapeutic targets and improve outcomes for this patient group.

Conclusions:

  • Pan-negative NSCLC presents unique challenges due to the absence of known actionable driver mutations.
  • Further research is needed to elucidate the molecular landscape and develop targeted treatments for pan-negative NSCLC.
  • Comprehensive characterization of pan-negative NSCLC is essential for improving patient prognosis and treatment strategies.
Keywords:
Driver geneLung neoplasmsPan-negative

More Related Videos

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

2.3K
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

2.8K

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.3K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.7K
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.4K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K