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Accidental Injection of Freund Complete Adjuvant With Mycobacterium Tuberculosis

Michael P Gaspar1, Genevieve Landes2, Farinaz Safavi3

  • 1The Philadelphia Hand to Shoulder Center, Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA; Darden School of Business, University of Virginia, Charlottesville, VA.

The Journal of Hand Surgery
|March 13, 2018
PubMed

Insights

Laboratory workers face risks from accidental needlestick injuries involving atypical pathogens. A case highlights the severe hand injury from self-injecting Freund complete adjuvant with Mycobacterium tuberculosis, necessitating extensive treatment.

Area of Science:

  • Microbiology
  • Occupational Health
  • Infectious Diseases

Background:

  • Accidental needlestick injuries are a significant risk for healthcare and laboratory personnel.
  • Exposure to atypical pathogens in animal research settings presents unique inoculation site challenges.

Observation:

  • A healthy laboratory worker accidentally injected Freund complete adjuvant containing heat-killed Mycobacterium tuberculosis into her hand.
  • The injury resulted in a severe inoculation site reaction.

Findings:

  • The patient required multiple surgical debridement procedures.
  • Treatment was prolonged due to the nature of the injected material.

Implications:

  • This case underscores the potential severity of self-inoculation injuries with specific laboratory materials.
  • Highlights the importance of stringent safety protocols when handling infectious agents and adjuvants.
  • Emphasizes the need for prompt and aggressive management of such occupational exposures.
Keywords:
Accidental injectionFreund complete adjuvantMycobacterium tuberculosisinadvertent needlesticklaboratory worker

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