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Electroporation of Functional Bacterial Effectors into Mammalian Cells
Published on: January 19, 2015
Update on regulation and effector functions of Th17 cells
1Center for Translational Research in Infection and Inflammation Tulane School of Medicine , JBJ 375, 333 S. Liberty Street, New Orleans, LA, USA.
Abstract:
T-helper cells that produce IL-17 are recognized as a significant subset within cell-mediated adaptive immunity. These cells are implicated in both the pathology of inflammatory disorders as well as the clearance of extracellular infections and the maintenance of the microbiota. However, the dynamic nature of this cell type has created controversy in understanding Th17 induction as well as Th17 phenotyping, since these cells may switch from Th17 to Treg or Th17 to Th1 cytokine profiles under certain conditions. This review highlights recent advances in Th17 cells in understanding their role in commensal regulation, sex difference in immune outcomes and the immunology of pregnancy, as well as inventive experimental models that have allowed for an increased understanding of Th17 regulation and induction.
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