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Orthodontics and Moebius syndrome: an observational study
Marisabel Magnifico1, Diana Cassi2, Mauro Gandolfini2
1Department of Medicine, University Center of Dentistry, University of Parma, Parma, Italy - marisabel.magnifico@libero.it.
Minerva Stomatologica
|March 13, 2018
Summary
Moebius syndrome (MS) patients often present with strabismus and limb malformations. Early orthodontic intervention with a multidisciplinary approach is recommended to manage associated clinical characteristics and improve patient outcomes.
Area of Science:
- Medical Genetics
- Neurology
- Orthodontics
Background:
- Moebius syndrome (MS) is a rare congenital disorder.
- Characterized by bilateral facial and abducens nerve paralysis.
- Affects multiple cranial nerves, leading to facial weakness and eye movement limitations.
Purpose of the Study:
- To evaluate the primary orthodontic features in Moebius syndrome patients.
- To determine the frequency of clinical characteristics associated with Moebius syndrome.
- To identify potential patterns for early orthodontic intervention.
Main Methods:
- Study included 58 patients diagnosed with Moebius syndrome.
- Patients' ages ranged from 8 months to 46 years.
- Utilized Terzis classification for assessment, including clinical and orthodontic examinations.
Main Results:
- Frequently observed associated conditions include strabismus, limb malformations, and cleft lip/palate.
- Reduced temporomandibular (TM) joint mobility was noted in 48% of patients.
- Cephalometric analysis revealed a higher prevalence of Class II malocclusion (56%) with micrognathia and maxillary overdevelopment, likely due to impaired lip seal.
Conclusions:
- Early orthodontic treatment is crucial for managing Moebius syndrome.
- A multidisciplinary approach is essential to mitigate the impact of sequelae.
- Intervention aims to reduce the long-term effects on patients and their families.
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