Related Experiment Video
Updated: Feb 13, 2026

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
Published on: March 13, 2013
A 18F radiolabelled Zn(ii) sensing fluorescent probe
Thomas W Price1, George Firth, Charlotte J Eling
1Biomedical Sciences, School of Life Sciences, University of Hull, Hull, UK. g.stasiuk@hull.ac.uk.
Abstract:
A selective fluorescent probe for Zn(ii), AQA-F, has been synthesized. AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(ii) ([AQA-F] = 0.1 mM, [Zn(ii)Cl2] = 0-300 microM). An enhancement of quantum yield from Φ = 4.2% to Φ = 35% is also observed. AQA-F has a binding constant, Kd = 15.2 microM with Zn(ii). This probe has been shown to respond to endogenous Zn(ii) levels in vitro in prostate and prostate cancer cell lines. [18F]AQA-F has been synthesized with a radiochemical yield of 8.6% and a radiochemical purity of 97% in 88 minutes. AQA-F shows the potential for a dual modal PET/fluorescence imaging probe for Zn(ii).
Related Concept Videos
The Sense of Self: Reflected Self-Appraisal and Social Comparison
Introduction to Special Senses
Tactile and Chemical Senses
Labeling DNA Probes
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Gene Regulation in Microbial Communities: Quorum Sensing
Photoluminescence: Fluorescence and Phosphorescence
A pair of electrons in a...

