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TryTransDB: A web-based resource for transport proteins in Trypanosomatidae
Krushna Sonar1, Ritika Kabra1, Shailza Singh2
1National Centre for Cell Science, NCCS Complex, Ganeshkhind, SP Pune University Campus, Pune, 411007, India.
Scientific Reports
|March 14, 2018
Summary
TryTransDB is a comprehensive database for Trypanosomatidae transport proteins. It offers BLAST searches, phylogenetic analysis, and links to other databases for integrated research.
Area of Science:
- Parasitology
- Molecular Biology
- Bioinformatics
Background:
- Transport proteins are crucial for Trypanosomatidae survival and pathogenesis.
- Existing resources lack integrated data and analysis tools for these proteins.
- Understanding transport proteins aids in developing therapeutic strategies.
Purpose of the Study:
- To develop TryTransDB, an integrated web-based resource for Trypanosomatidae transport proteins.
- To provide researchers with a centralized platform for accessing and analyzing transport protein data.
- To facilitate comparative and functional studies of these proteins.
Main Methods:
- Compilation of transport protein sequences (protein and nucleotide) from Trypanosomatidae organisms.
- Development of a web interface for data retrieval using a standalone BLAST tool.
- Integration of CLUSTALW for multiple sequence alignment (MSA) and phylogenetic tree computation.
- Implementation of cross-linking functionalities to external biological databases.
Main Results:
- TryTransDB provides comprehensive access to Trypanosomatidae transport protein data.
- The integrated BLAST tool enables efficient sequence similarity searches.
- Phylogenetic analysis capabilities are available within the resource.
- Cross-linking enhances data accessibility and facilitates further investigation.
Conclusions:
- TryTransDB serves as a valuable one-stop resource for researchers studying Trypanosomatidae transport proteins.
- The integrated tools streamline data analysis and comparative studies.
- This database will advance research into the function and potential drug targets of these proteins.
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