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From checkpoint to checkpoint: DNA damage ATR/Chk1 checkpoint signalling elicits PD-L1 immune checkpoint activation

Kent W Mouw1, Panagiotis A Konstantinopoulos2

  • 1Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.

British Journal of Cancer
|March 14, 2018
PubMed

Insights

Genomic instability impacts anti-PD-1/PD-L1 therapy response. The ATR/Chk1 DNA damage pathway regulates PD-L1 expression, offering new avenues for cancer treatment selection and study design.

Area of Science:

  • Oncology
  • Cancer Immunology
  • Molecular Biology

Background:

  • Genomic instability is linked to patient response to immune checkpoint inhibitors like anti-PD-1/PD-L1 therapy.
  • The precise mechanisms underlying this link are under investigation.
  • Understanding these mechanisms is crucial for optimizing cancer treatment strategies.

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