The MPA test: a reevaluation

The response to the administration of Medroxy-progesterone Acetate (MPA) is nowadays widely employed as an indirect index of oestrogen level in women with secondary amenorrhea. The Authors studied the relationship between the response to the MPA test and the activity of the Hypothalamic-pituitary-ovarian axis: they also compared the MPA test with other endocrinological investigations, such as the GnRH and Clomiphene citrate tests. Furthermore, MPA was compared to Noretisterone acetate and to rectally administered pure Progesterone in order to ascertain their pharmacodynamic features.