Related Experiment Video
Updated: Aug 4, 2026
12:11
Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
Published on: May 11, 2017
Use of new biologic markers in the ovulation induction
A Silvestri1, F Scarpellini, N Dino
1II 1st. Ob/Gyn, Università La Sapienza, Roma.
Acta Europaea Fertilitatis
|July 1, 1995
Summary
Platelet Factor IV is the most reliable biological marker for assessing ovulation, outperforming albuminemia and estrogenic receptors. This finding offers a more dependable method for monitoring hormonal ovulatory status in women.
Area of Science:
- Reproductive Endocrinology
- Biomarker Discovery
- Gynecology
Background:
- Traditional ovulation markers are declining due to advancements in biochemical and biophysical methods.
- Hormonal effects during ovulation manifest as biological changes in target tissues.
- Investigating non-reproductive target tissues may reveal novel ovulation markers.
Purpose of the Study:
- To evaluate biological modifications in non-reproductive tissues as potential markers of ovulation.
- To compare the efficacy of Albuminemia, Platelet Factor IV, and Type II estrogenic receptors in indicating ovulation.
Main Methods:
- Studied 42 women undergoing induced ovulation.
- Monitored Albuminemia, Platelet Factor IV (indicator of Platelet Aggregation), and Type II estrogenic receptors.
- Compared marker behavior in 33 women with successful ovulation versus 9 with Luteinized Unruptured Follicle (LUF) syndrome.
Main Results:
- All evaluated markers demonstrated sufficient sensitivity in detecting ovulatory status.
- Platelet Factor IV showed the highest reliability in reflecting the hormonal ovulatory situation.
- Albuminemia and Type II estrogenic receptors also showed sensitivity but were less consistent than Platelet Factor IV.
Conclusions:
- Platelet Factor IV emerges as a highly reliable biomarker for assessing ovulation.
- Non-reproductive tissue markers, particularly Platelet Factor IV, can effectively indicate hormonal ovulatory status.
- This research provides a more dependable biological marker for ovulation monitoring.
