Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

60.2K
Overview
60.2K
Variability: Analysis01:11

Variability: Analysis

528
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
528
Random Variables01:09

Random Variables

17.9K
A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
17.9K
Graphs of Equations in Two Variables01:30

Graphs of Equations in Two Variables

273
An equation with two variables, typically written in the form y = f(x) or Ax + By = C, describes a relationship between quantities represented by x and y. Each solution to such an equation is an ordered pair (x, y) that satisfies the equation when substituted. These pairs can be represented graphically to understand the variables' relationship visually.A common technique for constructing the graph of a two-variable equation is to create a value table. Begin by choosing several values for the...
273
Variables Affecting Phosphorescence and Fluorescence01:26

Variables Affecting Phosphorescence and Fluorescence

1.5K
Fluorescence and phosphorescence are essential phenomena in fields like analytical chemistry, biological imaging, and materials science, where they detect molecular properties and visualize cellular structures. Understanding the variables that influence these luminescent behaviors is crucial for maximizing accuracy and efficiency in their applications. These variables can broadly be grouped into chemical structure, solvent properties, and external conditions, each playing a distinct role in...
1.5K
Work and Energy for Variable Forces01:10

Work and Energy for Variable Forces

5.8K
When an object is acted upon by a variable force, the amount of work done and the change in energy of the object can be more complex to calculate compared to when a constant force is applied. Work is the product of force and displacement, while energy is the capacity of a system to do work. When a constant force is applied to an object, the work done can be calculated as the product of the force and the distance moved in the direction of the force. However, when a variable force is applied, the...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal characterization of variation in neuronal types in the mouse basal ganglia.

bioRxiv : the preprint server for biology·2026
Same author

Connecting single-cell transcriptomes to projectomes in the mouse visual cortex.

Nature·2026
Same author

Psychometric validation of the Angioedema Quality of Life Questionnaire (AE-QoL) for hereditary angioedema.

Journal of patient-reported outcomes·2026
Same author

Anticoagulation Changes and Biochemical Signals Preceding Hospital-Acquired Infections in Pediatric Extracorporeal Support.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

The changing landscape of outpatient antibiotic prescriptions among advanced practice clinicians in the United States, 2011 and 2022.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026
Same author

Check Engine Light, Red Herring, or MacGuffin? Clinician-Level Correlations of the Antibiotic Utilization for Respiratory Conditions (AXR) Metric With Outpatient Antimicrobial Stewardship Metrics, Diagnostic Practices, and Prescription Characteristics.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026

Related Experiment Video

Updated: Feb 13, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.7K

Variability in Antibiotic Use Across PICUs.

Thomas V Brogan1, Cary Thurm2, Adam L Hersh3

  • 1Division of Pediatric Critical Care Medicine, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA.

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|March 14, 2018
PubMed
Summary

Antibiotic prescribing varies widely across pediatric intensive care units (PICUs), indicating potential overuse. This study analyzed antibiotic use in PICUs from 2010-2014, revealing significant institutional differences.

More Related Videos

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

8.0K
Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
08:23

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes

Published on: March 2, 2020

13.6K

Related Experiment Videos

Last Updated: Feb 13, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.7K
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

8.0K
Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
08:23

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes

Published on: March 2, 2020

13.6K

Area of Science:

  • Pediatric critical care medicine
  • Infectious disease epidemiology
  • Antimicrobial stewardship

Background:

  • Antibiotic prescribing patterns in pediatric intensive care units (PICUs) can significantly impact patient outcomes and contribute to antimicrobial resistance.
  • Variability in antibiotic use among different institutions may suggest differences in clinical practice or adherence to guidelines.

Purpose of the Study:

  • To characterize and compare antibiotic prescribing practices across multiple PICUs.
  • To evaluate the extent of variability in antibiotic use among children's hospitals.

Main Methods:

  • Retrospective analysis of the Pediatric Health Information System database from 2010 to 2014.
  • Inclusion of data from 41 freestanding children's hospitals, encompassing over 3 million discharges and 386,000 PICU patients.
  • Subanalysis using All Patient Refined-Diagnosis Related Groups to normalize for disease severity and case mix.

Main Results:

  • Overall antibiotic use declined during the study period, but remained higher in PICU patients compared to non-ICU children.
  • Significant institutional variability was observed in overall antibiotic use, broad-spectrum antibiotic use, and use of specific agents like antimethicillin-resistant Staphylococcus aureus agents.
  • This variability persisted even after adjusting for potential confounders such as disease severity and case mix.

Conclusions:

  • Wide variation in antibiotic use across children's hospital PICUs suggests potential for inappropriate prescribing.
  • Findings highlight the need for standardized antibiotic stewardship programs and further investigation into the drivers of prescribing variability.