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Related Experiment Videos

'Massive' metformin overdose.

Angela L Chiew1, Daniel F B Wright2, Nicola M Dobos3

  • 1New South Wales Poisons Information Centre, Children's Hospital at Westmead, Westmead, New South Wales, Australia.

British Journal of Clinical Pharmacology
|March 14, 2018
PubMed
Summary

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This summary is machine-generated.

Massive metformin overdose caused severe metabolic acidosis and hyperlactatemia. Intermittent haemodialysis (IHD) improved acidosis, unlike continuous venovenous haemodiafiltration (CVVHDF), leading to patient survival.

Area of Science:

  • Toxicology
  • Nephrology
  • Pharmacology

Background:

  • Metformin overdose can lead to life-threatening metabolic acidosis and hyperlactatemia.
  • High-dose metformin ingestion requires intensive management strategies.
Keywords:
extracorporeal eliminationmetabolic acidosismetforminoverdose

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