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Published on: August 6, 2019
New Naphthoquinone Terpenoids from Marine Actinobacterium, Streptomyces sp. CNQ-509
Jin-Soo Park1, Hak Cheol Kwon2
1Natural Constituents Research Center, Korea Institute of Science and Technology (KIST), Gangneung, Gangwon-do 25451, Korea. jinsoopark@kist.re.kr.
Abstract:
A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivatives (1 and 2) comprised of naphthoquinone and geranyl moieties along with the known terpenoid, debromomarinone. The two-dimensional structure of these compounds was determined through spectral data analysis using data from NMR, MS and UV spectroscopy. Furthermore, the full structures of 1 and 2 including absolute configurations were unequivocally established by a combination of NMR experiments and chemical modifications.
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