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Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities

Manuela Porru1, Luca Pompili1,2, Carla Caruso2

  • 1UOSD SAFU, Regina Elena National Cancer Institute, Rome, Italy.

Journal of Experimental & Clinical Cancer Research : CR
|March 15, 2018
PubMed

Insights

Targeting KRAS, a key cancer-driving oncogene, has been difficult for 30 years. This review covers new strategies for blocking KRAS function and signaling, including our group's research findings.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • KRAS is the most frequently mutated oncogene in human cancers.
  • Despite extensive efforts over 30 years, developing effective KRAS-targeting drugs has remained a significant challenge.
  • KRAS plays a critical role as a driver oncogene in cancer development and progression.

Purpose of the Study:

  • To review emerging experimental strategies for inhibiting KRAS function and signaling pathways.
  • To discuss the direct targeting of KRAS as a therapeutic approach.
  • To present research findings from our group in the field of KRAS drug development.

Main Methods:

  • Literature review of current KRAS targeting strategies.
  • Analysis of experimental approaches for blocking KRAS activity.
  • Presentation of original research data on KRAS targeting.

Main Results:

  • Highlighting novel experimental strategies for KRAS inhibition.
  • Demonstrating progress in directly targeting KRAS.
  • Reporting specific results achieved by our research group in this area.

Conclusions:

  • Pharmacological targeting of KRAS remains a critical unmet need in cancer therapy.
  • Emerging strategies show promise for overcoming previous challenges in KRAS drug development.
  • Continued research, including our group's contributions, is vital for advancing KRAS-targeted cancer treatments.

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