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Related Experiment Video

Updated: Feb 13, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
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Menthol Cough Drops: Cause for Concern?

Danika Johnson1, Robert Mead1, Korey Kennelty1

  • 1From the University of Wisconsin School of Medicine & Public Health, Madison, WI (DJ); Department of Primary Care, Bellin Health System, Green Bay (RM); College of Pharmacy, University of Iowa, Iowa City, IA (KK); Department of Family & Community Medicine, University of Wisconsin School of Medicine & Public Health, Madison (DH).

Journal of the American Board of Family Medicine : JABFM
|March 15, 2018
PubMed
Summary
This summary is machine-generated.

Excessive menthol in cough drops may worsen cough symptoms, especially with higher daily consumption. Clinicians should inquire about cough drop use in patients with persistent coughs.

Keywords:
CoughMedical History TakingMentholOver-the-Counter DrugsPrimary Health CareWisconsin

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Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Public Health

Background:

  • Over-the-counter (OTC) cough remedies, including cough drops, are minimally regulated, potentially masking side effects.
  • Millions of cough drops are sold annually in the US, with a clinician observing potential harm from excessive use.
  • A study was initiated to investigate the link between menthol in cough drops and exacerbated cough symptoms.

Purpose of the Study:

  • To assess the relationship between menthol content in cough drops and the severity of cough symptoms.
  • To determine if menthol consumption influences cough duration or severity in patients presenting with acute or subacute coughs.

Main Methods:

  • A voluntary, anonymous survey on cough drop usage was administered to 548 adolescent and adult outpatients with acute or subacute coughs across 5 primary care clinics.
  • Data collected included demographics, smoking status, cough severity and duration, and details of cough drop consumption (type and amount).
  • Statistical analyses, including univariate and multivariable models, were used to examine associations between cough drop use, menthol content, and cough characteristics.

Main Results:

  • Cough drop use was associated with a longer cough duration (P < .001) but not significantly with overall cough severity (P = .09).
  • Among cough drop users, 90% consumed mentholated drops.
  • Significant associations were found between increased cough severity and higher average menthol dose per drop, daily consumption, and total daily menthol intake, even after controlling for confounding factors (P = .003).

Conclusions:

  • The amount of menthol consumed from cough drops may negatively impact cough severity in certain individuals.
  • Healthcare providers should routinely ask about cough drop consumption during patient history taking for persistent coughs.
  • Further research is recommended to elucidate the potential mechanisms underlying menthol's effect on cough symptoms.