Normative Trimester-Specific Thyroid Function Data from India: The State of the Nation

Area of Science:

• Endocrinology
• Reproductive Health
• Public Health

Background:

• International guidelines advocate for local trimester-specific thyroid stimulating hormone (TSH) normative data.
• Currently, a lack of unified Indian data for trimester-specific TSH ranges exists.

Purpose of the Study:

• To review and discuss the current state of trimester-specific TSH ranges in India.
• To highlight the need for comprehensive, pan-India TSH normative data.

Main Methods:

• Systematic collation of recently published TSH data from various Indian centers.
• Analysis of the strengths and limitations of existing Indian TSH datasets.

Main Results:

• Available Indian TSH data is fragmented, with varying strengths and limitations.
• The current data is insufficient to establish unified national normative ranges.

Conclusions:

• Harmonized, multi-center research is essential to establish national normative TSH data for India.
• Establishing national TSH ranges will facilitate effective screening and management of thyroid dysfunction in pregnancy.