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Highly Photosensitive Poly-Sulfur-Bridged Chetomin Analogues from Chaetomium cochliodes
Meng-Hua Wang1, You-Cai Hu2, Bing-Da Sun3
1Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100193 , P.R. China.
Abstract:
The highly photosensitive characteristic of poly-sulfide chetomins was first unveiled, and four new unstable analogues, chetomins A-D (1-4), with significant cytotoxicity were successfully purified in darkness. The visible-light-induced desulfurization and intermolecular disproportionation were revealed to initiate the interconversion of chetomin analogues, which explained the long-recognized puzzle of rarity and instability of chetomin analogues.
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