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Related Concept Videos

Classification of Illness01:17

Classification of Illness

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The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
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Factors Affecting Illness01:18

Factors Affecting Illness

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When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
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Development of the Lymphatic System01:15

Development of the Lymphatic System

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
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Concepts of Health and Illness01:29

Concepts of Health and Illness

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Health is a condition of the body, mind, and spirit where an individual remains free from illness. Similarly, wellness is an active state, including living a lifestyle that promotes physical, mental, and emotional health. Physical health is critical for the overall well-being and can be affected by lifestyle, activity level, diet, and behavior. The highest attainable standard of health is a fundamental and universal human right. Consider Lisa, a fifteen-year-old born with congenital...
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Dimensions of Health and Illness01:21

Dimensions of Health and Illness

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The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
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Critical Region, Critical Values and Significance Level01:16

Critical Region, Critical Values and Significance Level

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The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in  probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
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Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
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Lymphatic dysfunction in critical illness.

Edmund Burke1, Sanjeev A Datar

  • 1Department of Pediatrics, Division of Critical Care Medicine, University of California, San Francisco and Benioff Children's Hospitals, San Francisco, CA, USA.

Current Opinion in Pediatrics
|March 15, 2018
PubMed
Summary
This summary is machine-generated.

The lymphatic system is vital for fluid balance and immunity, but its function in critical illness is poorly understood. New therapies targeting lymphatic disorders are emerging, offering hope for improved patient outcomes.

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Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
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Area of Science:

  • Pediatric Intensive Care Medicine
  • Lymphatic Biology
  • Vascular Physiology

Background:

  • The lymphatic system is crucial for fluid homeostasis, nutrient transport, and immune cell trafficking.
  • Its role in critical illness, including systemic inflammation and respiratory failure, is significant but not fully understood.
  • Congenital and acquired lymphatic disorders impact pediatric patients in intensive care settings.

Purpose of the Study:

  • To review structural and functional lymphatic disorders in pediatric intensive care.
  • To explore novel medical and procedural therapeutic interventions for lymphatic dysfunction.
  • To highlight advancements in understanding lymphatic biology and its clinical implications.

Main Methods:

  • Review of current literature on lymphatic system disorders and therapies.
  • Discussion of diagnostic advancements like dynamic contrast-enhanced magnetic resonance lymphangiography.
  • Examination of emerging pharmacologic targets, including mTOR and leukotriene B4 signaling inhibitors.

Main Results:

  • Current therapies for lymphatic abnormalities are often nonspecific or surgical.
  • Image-directed percutaneous interventions are poised to replace traditional surgery.
  • Phase II clinical trials are investigating mTOR and leukotriene B4 signaling inhibitors for lymphatic disorders.

Conclusions:

  • Advances in lymphatic biology are paving the way for novel therapeutic strategies.
  • Enhanced understanding will enable better support for lymphatic function during critical illness and recovery.
  • Future research aims to augment lymphatic function for improved patient convalescence.