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Childhood-onset pityriasis rubra pilaris with immunologic abnormalities

D Shvili, M David, M Mimouni

    Pediatric Dermatology
    |May 1, 1987
    PubMed

    Insights

    This study reports a case of pityriasis rubra pilaris in a child, identified by characteristic skin lesions and biopsy findings. Immunologic evaluation revealed altered T cell activity, suggesting a potential role in the condition.

    Area of Science:

    • Dermatology
    • Immunology

    Background:

    • Seborrheic dermatitis-like facial redness, scalp scaling, and palmoplantar keratoderma can present in pediatric patients.
    • Pityriasis rubra pilaris (PRP) is a rare chronic disorder of keratinization.

    Observation:

    • A 6-year-old boy presented with facial redness, scalp scaling, and palmoplantar keratoderma.
    • Skin biopsy revealed hyperkeratosis, parakeratosis, follicular plugging, and a mild perifollicular inflammatory infiltrate, consistent with PRP.

    Findings:

    • Peripheral B and T lymphocyte counts were normal.
    • Immunologic studies indicated activated T suppressor cell activity and impaired T helper cell function.

    Implications:

    • This case highlights the dermatoscopic and histopathological features of pediatric PRP.
    • Altered T cell function may contribute to the pathogenesis of pityriasis rubra pilaris.
    • Further research into immunologic dysregulation in PRP is warranted.

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