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A quantitative method for staging mouse embryos based on limb morphometry.

Marco Musy1,2,3, Kevin Flaherty4, Jelena Raspopovic5,2

  • 1Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology Dr. Aiguader 88, Barcelona 08003, Spain marco.musy@embl.es james.sharpe@embl.es.

Development (Cambridge, England)
|March 16, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a new method to determine embryonic mouse developmental stages using limb bud shape. This tool, eMOSS, accurately stages embryos, aiding in the study of limb development and abnormalities.

Keywords:
Limb growthMorphometricsMouse developmentOsterixSonic hedgehogStaging systemeMOSS

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Area of Science:

  • Developmental Biology
  • Morphometrics
  • Bioinformatics

Background:

  • Accurate staging of embryonic development is crucial for understanding morphogenesis.
  • Traditional methods for staging mouse embryos can be time-consuming and subjective.
  • Limb bud development exhibits distinct morphological changes throughout embryogenesis.

Purpose of the Study:

  • To develop a quantitative method for determining embryonic mouse developmental stages.
  • To create a standardized ontogenetic trajectory for mouse limb bud development.
  • To introduce a freely available online tool for staging mouse embryos.

Main Methods:

  • Application of geometric morphometrics to analyze shape changes in mouse limb buds from embryonic day 10 to 15.
  • Creation of a standard ontogenetic trajectory representing limb bud shape evolution.
  • Development of the embryonic mouse ontogenetic staging system (eMOSS) based on limb bud morphology.

Main Results:

  • A quantitative characterization of limb bud shape change during morphogenesis was established.
  • The developed trajectory allows inference of developmental stage from limb bud shape with a typical uncertainty of 2 hours.
  • The eMOSS tool was created as a fast, reliable, and accessible online resource for embryo staging.

Conclusions:

  • The eMOSS system provides a precise and efficient method for staging embryonic mice.
  • This tool facilitates the phenotyping of early limb abnormalities.
  • The quantitative approach advances the understanding of limb bud morphogenesis and developmental timing.