[Artificial pancreas in diabetic children].

Area of Science:

• Biomedical Engineering
• Endocrinology
• Metabolic Research

Background:

• Current artificial pancreas systems are primarily for research, not wearable devices.
• These systems have potential applications in clinical and therapeutic diabetes mellitus investigations.

Purpose of the Study:

• To demonstrate the utility of non-wearable artificial pancreases in diabetes research.
• To explore the clinical and therapeutic applications of artificial pancreas technology.

Main Methods:

• Utilized the Biostator artificial pancreas in a study of 300 young individuals with diabetes.
• Employed steady-state plasma glucose regulation for various investigations.

Main Results:

• Demonstrated the Biostator's effectiveness in clinical investigations, including insulin resistance measurement and glucose/renal threshold analysis.
• Evaluated therapeutic applications such as hypoglycemic activity of insulins and alternative administration routes (e.g., peritoneum).
• Facilitated physiopathological studies by measuring substrate turnover for metabolic alterations in diabetes.

Conclusions:

• Experience with artificial pancreases is vital for advancing the design of future wearable and implantable diabetes devices.
• Artificial pancreas technology offers significant potential for diabetes mellitus research and management.