Related Experiment Video
Updated: Feb 13, 2026

Imaging Neurons within Thick Brain Sections Using the Golgi-Cox Method
Published on: April 18, 2017
Sesquiterpene Lactones with COX-2 Inhibition Activity from Artemisia lavandulaefolia
Jie-Li Lü1, Zhou Li1, Li-Min Guo1
1School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, P. R. China.
Abstract:
Two new sesquiterpene lactones, artelavanolides A (1) and B (2), and four known sesquiterpene lactones (3 - 6) were isolated from the leaves of Artemisia lavandulaefolia. Their structures were elucidated based on the analysis of spectroscopic data (1D, 2D-NMR and HR-ESI-MS). The absolute configuration of 1 was determined by the analysis of single-crystal X-ray diffraction data. Artelavanolide A (1) is a rare sesquiterpene lactone possessing an unusual skeleton with the linkage of Me(14)-C(1) that is probably formed through a rearrangement of the guaiane-type sesquiterpenoids. Artelavanolide B (2) is a new highly unsaturated guaianolide. Compounds 1 - 6 were tested for activities on the inhibition of COX-2 enzyme in vitro. All of compounds exhibited inhibitory activity against COX-2 with IC50 values ranging from 43.29 to 287.07 μm compared with the positive control, celecoxib (IC50 = 18.10 μm). Among them, 3 showed the best COX-2 inhibitory activity with an IC50 value of 43.29 μm.
More Related Videos
10:17Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
06:53Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
Published on: November 23, 2011
Related Concept Videos
Inhibition of Cdk Activity
Feedback Inhibition
The Mantel-Cox Log-Rank Test
Enzyme Inhibition
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Co-activators and Co-repressors