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In Utero Intraventricular Injection and Electroporation of E16 Rat Embryos
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Intraventricular neurocytoma : a clinical and electro-microscopic study
T V Rao1, P N Jayakumar1, Y Ramamohan1
1Department of Neuropathology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore - 560029, India.
Neurology India
|March 16, 2018
Summary
Intraventricular neurocytomas are rare tumors often misdiagnosed as oligodendroglioma. Electron microscopy is crucial for accurate diagnosis, distinguishing these neurocytomas from other brain tumors.
Area of Science:
- Neuropathology
- Neurosurgery
- Oncology
Background:
- Intraventricular neurocytomas are rare tumors that can be misdiagnosed as oligodendroglioma due to similar light microscopy features.
- Accurate diagnosis is essential for appropriate patient management and prognosis.
Purpose of the Study:
- To highlight the diagnostic challenges of intraventricular neurocytomas.
- To emphasize the utility of electron microscopy (EM) in differentiating these tumors from oligodendrogliomas.
- To discuss the prognostic implications of neuronal versus glial differentiation in neurocytomas.
Main Methods:
- Case series of three intraventricular tumors.
- Diagnostic evaluation included CT scan and routine light microscopy.
- Definitive diagnosis was established using electron microscopy (EM).
Main Results:
- All three cases were initially misdiagnosed as oligodendroglioma based on CT and light microscopy.
- Electron microscopy revealed characteristic features of neurocytoma, including cells with multiple processes, abundant rough endoplasmic reticulum (RER), dense core vesicles, and axon terminals with synaptic vesicles.
- The presence of these ultrastructural features confirmed the diagnosis of intraventricular neurocytoma.
Conclusions:
- Intraventricular neurocytomas require careful diagnostic evaluation, often necessitating electron microscopy for definitive identification.
- Electron microscopy is a valuable tool for distinguishing neurocytomas from oligodendrogliomas.
- The prognosis of neurocytomas may be influenced by the extent of neuronal and glial differentiation.
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