Meningiomas Following the Previous Cancer Therapies: Brief Report

Area of Science:

• Neuro-oncology
• Radiation oncology
• Pediatric oncology

Background:

• Ionizing radiation and chemotherapy are known to induce secondary brain tumors, including meningiomas and gliomas.
• The literature on treatment-induced tumorigenesis is sparse, with limited understanding of underlying mechanisms.
• Recent molecular studies offer new insights into the pathogenesis of radiation-induced meningiomas.

Purpose of the Study:

• To highlight recent updates in the understanding of brain tumor development following cancer treatment.
• To present cases of meningioma development in patients treated for childhood malignancies.
• To emphasize the need for long-term follow-up in survivors of childhood cancer.

Main Methods:

• Case report of two patients treated for childhood malignancy.
• Review of current literature on radiation- and chemotherapy-induced brain tumors.
• Discussion of emerging molecular and genetic insights into meningioma pathogenesis.

Main Results:

• Two patients developed meningiomas years after childhood cancer treatment.
• Surgical removal of meningiomas resulted in favorable clinical outcomes.
• The molecular and genetic basis for radiation-induced meningiomas is increasingly understood.

Conclusions:

• Cancer survivors, particularly those treated in childhood, may be at increased risk for secondary meningiomas.
• Long-term surveillance is essential for early detection and management of these secondary tumors.
• Understanding the biomolecular pathogenesis is critical for effective clinical management and risk stratification.