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Strain-Promoted Cycloaddition of Cyclopropenes with o-Quinones: A Rapid Click Reaction
Digvijay Gahtory1, Rickdeb Sen1, Andriy R Kuzmyn1
1Laboratory of Organic Chemistry, Wageningen University and Research, Stippeneng 4, 6708, WE, Wageningen, The Netherlands.
Abstract:
Novel click reactions are of continued interest in fields as diverse as bio-conjugation, polymer science and surface chemistry. Qualification as a proper "click" reaction requires stringent criteria, including fast kinetics and high conversion, to be met. Herein, we report a novel strain-promoted cycloaddition between cyclopropenes and o-quinones in solution and on a surface. We demonstrate the "click character" of the reaction in solution and on surfaces for both monolayer and polymer brush functionalization.
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