Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extracellular Matrix01:42

The Extracellular Matrix

89.5K
Overview
89.5K
The Extracellular Matrix01:29

The Extracellular Matrix

12.4K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.4K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.6K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.6K
Extracellular Matrix01:26

Extracellular Matrix

5.6K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.6K
Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
Embryonic Stem Cells00:58

Embryonic Stem Cells

32.6K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipid metabolism as a marker for glioma aggressiveness.

Bioscience reports·2026
Same author

Integrative RNA-Seq and TCGA-BRCA Analyses Highlight the Role of LINC01133 in Triple-Negative Breast Cancer.

Biomedicines·2026
Same author

Magnetic Bead-Guided Assembly of 3D Primary Human Islet Cells in Decellularized Pancreatic Scaffolds.

Cells·2026
Same author

Glutamine metabolism tunes myeloid responses to drive resolution of inflammation during skin repair.

Cell reports·2026
Same author

A Deletion Variant of Human Factor VIII Displaying Low Immunogenicity in a Murine Model of Hemophilia A.

International journal of molecular sciences·2025
Same author

Exploring Bioactive Polysaccharides in Edible Fruits: A Cross-Biome Perspective.

Plants (Basel, Switzerland)·2025
Same journal

Coming full circle: Neural crest marker FOXD3 regulates SHH expression in the floorplate and neural tube morphogenesis.

Developmental biology·2026
Same journal

The oocytes of basal dermapterans lack the posterior pole lysosomal compartment (PPLC).

Developmental biology·2026
Same journal

A central role for Islr2 (Linx) in direct pathway striatal projection neurons for the correct formation of the internal capsule and cerebral peduncle.

Developmental biology·2026
Same journal

Shared candidate genes associated with variation in egg size in cold-adapted and artificially selected Drosophila melanogaster.

Developmental biology·2026
Same journal

The molecular mechanism underlying melatonin-mediated repair of ovarian damage in mice exposed to abnormal light cycles.

Developmental biology·2026
Same journal

The Drosophila ovarian terminal filament imports lipophilic molecules that support cyst and follicle development within the ovariole.

Developmental biology·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells
11:41

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

Published on: December 16, 2018

6.1K

Extracellular matrix dynamics during mesenchymal stem cells differentiation.

Thais Assis-Ribas1, Maria Fernanda Forni2, Sheila Maria Brochado Winnischofer3

  • 1NUCEL-NETCEM-Faculdade de Medicina, Departamento de Clínica Médica, Universidade de São Paulo, São Paulo, SP 05360-120, Brazil.

Developmental Biology
|March 17, 2018
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) hold therapeutic potential but their in vivo roles are unclear. Extracellular matrix regulators like MMPs and TIMPs significantly influence MSC differentiation into fat, bone, and cartilage.

More Related Videos

Isolation of Human Mesenchymal Stem Cells and their Cultivation on the Porous Bone Matrix
09:00

Isolation of Human Mesenchymal Stem Cells and their Cultivation on the Porous Bone Matrix

Published on: February 9, 2015

28.5K
Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
07:03

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

2.6K

Related Experiment Videos

Last Updated: Feb 13, 2026

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells
11:41

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

Published on: December 16, 2018

6.1K
Isolation of Human Mesenchymal Stem Cells and their Cultivation on the Porous Bone Matrix
09:00

Isolation of Human Mesenchymal Stem Cells and their Cultivation on the Porous Bone Matrix

Published on: February 9, 2015

28.5K
Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
07:03

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

2.6K

Area of Science:

  • Stem Cell Biology
  • Extracellular Matrix Biology
  • Tissue Engineering

Background:

  • Mesenchymal stem cells (MSCs) possess self-renewal and multipotent differentiation capabilities.
  • The in vivo identity and therapeutic applications of MSCs remain incompletely understood.
  • The impact of the MSC niche, including the extracellular matrix (ECM), on differentiation and homeostasis is under investigation.

Purpose of the Study:

  • To review the mechanisms of adipogenesis, chondrogenesis, and osteogenesis in MSCs.
  • To discuss the influence of the ECM on MSC lineage commitment, survival, and potential.
  • To critically analyze the roles of Matrix Metalloproteinases (MMPs) and their inhibitors (TIMPs, RECK) in MSC differentiation.

Main Methods:

  • Literature review of recent research on MSC differentiation.
  • Analysis of mechanisms governing adipogenesis, chondrogenesis, and osteogenesis.
  • Focus on the interplay between ECM components and MSC fate.

Main Results:

  • The ECM significantly impacts MSC lineage commitment and survival.
  • Matrix Metalloproteinases (MMPs) and their inhibitors (TIMPs, RECK) are key regulators of MSC differentiation.
  • Understanding these interactions is crucial for advancing MSC-based therapies.

Conclusions:

  • The ECM plays a critical role in regulating MSC differentiation and homeostasis.
  • MMPs and their inhibitors are essential mediators of MSC fate decisions.
  • Further research into MSC-ECM interactions will enhance cell therapy strategies.