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The role of Aurora-A in cancer stem cells

Minle Li1, Keyu Gao2, Laili Chu1

  • 1Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou, Jiangsu, 221002, China.

The International Journal of Biochemistry & Cell Biology
|March 17, 2018
PubMed

Insights

Aurora kinase A (Aurora-A) is crucial for cell division and stem cell self-renewal. Inhibiting Aurora-A shows promise for eliminating cancer stem cells and treating various cancers.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Aurora kinase A (Aurora-A) is a serine/threonine kinase vital for mitotic progression.
  • Aberrant Aurora-A expression is linked to human cancers and stem cell properties.

Purpose of the Study:

  • To review the role of Aurora-A in cancer stem cells.
  • To summarize clinical trial outcomes for Aurora-A inhibitors.

Main Methods:

  • Literature review of Aurora-A's function in cell cycle and stemness.
  • Analysis of clinical trial data for Aurora-A inhibitors.

Main Results:

  • Aurora-A regulates embryonic stem cell self-renewal and oncogenic transformation.
  • Aurora-A inhibition can eliminate leukemia stem cells.
  • Clinical trials assess small molecule inhibitors targeting Aurora-A.

Conclusions:

  • Aurora-A is a significant target for cancer therapeutics.
  • Targeting Aurora-A holds potential for eliminating cancer stem cells and treating malignancies.
Keywords:
Aurora-AAurora-A inhibitorsCancer stem cells

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