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Multimorbidity medications and poor asthma prognosis
Sébastien Chanoine1,2,3, Margaux Sanchez4,5, Isabelle Pin1,6
1Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Grenoble, France.
The European Respiratory Journal
|March 17, 2018
Summary
Elderly women with asthma often take multiple medications. Specific medication profiles linked to comorbidities increased risks of uncontrolled asthma and exacerbations, impacting quality of life.
Area of Science:
- Geriatric Medicine
- Pharmacology
- Respiratory Medicine
Background:
- Multimorbidity and polypharmacy are prevalent in elderly asthma patients.
- Understanding medication patterns is crucial for managing asthma in older adults.
Purpose of the Study:
- To characterize medication use in elderly women with asthma.
- To assess the impact of multimedication on asthma prognosis.
Main Methods:
- Network-based analysis of drug administrative databases.
- Clustering of medication profiles in 4328 elderly women with asthma.
- Association of medication profiles with adverse asthma events.
Main Results:
- Asthma patients exhibited higher multimedication rates compared to non-asthma patients.
- Three distinct medication profiles were identified: few, allergic, and metabolic comorbidity-related.
- Allergic and metabolic profiles were associated with increased risk of uncontrolled asthma, exacerbations, and reduced quality of life.
Conclusions:
- Integrative analysis revealed specific multimorbidity-related medication profiles impacting asthma prognosis.
- These findings highlight the significance of multimorbidity management in elderly asthma care.
- Addressing unmet needs in asthma management requires considering comorbidity medication patterns.
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