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Updated: Feb 13, 2026

Endoscopic Cholesteatoma Surgery
Published on: January 19, 2022
A novel haemostatic agent based on self-assembling peptides in the setting of nasal endoscopic surgery, a case series
1Royal Prince Alfred Hospital, 50 Missenden Rd, Camperdown, NSW, 2050, Australia.
Introduction:
Recently, a novel purely synthetic topical haemostatic agent (PuraStat®) has been proposed in surgery based on the self-assembling tendency of some repeating peptide sequences. This transparent, ready to use hydrogel appears suitable for use in FEES with low rates of post-operative re-bleeding and adhesion formation.A first series of 60 patients experiencing endonasal powered turbinoplasty across various hospitals in Sydney using PuraStat® was observed for postoperative re-bleeding and adhesion formation.
Discussion:
In all 60 patients, no post-operative re-bleeding was observed, while healing went well in absence of adhesion formation. Effective haemostasis with PuraStat® is well documented in other surgical fields, but its use in FEES and adhesion prevention is relatively novel.
Conclusion:
Synthetic self-assembling peptides appear to be indicated in this area. Further studies are needed to confirm their potential for adhesion prevention.
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