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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Regioselective synthesis of unsymmetrical biheteroaryls via copper(ii)-catalyzed cascade annulation
Sadhanendu Samanta1, Alakananda Hajra1
1Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India. alakananda.hajra@visva-bharati.ac.in.
Abstract:
A facile and efficient copper-catalyzed cascade annulation of an imidazoheterocycle with salicylaldehyde, piperidine, and terminal alkyne was developed to afford unsymmetrical biheteroaryl derivatives. A variety of biheteroaryl structural motifs containing furans and imidazoheterocycles have been synthesized in ambient air in high yields. The experimental results suggest that the reaction proceeds through a sequential non-radical 5-exo-dig cyclization process.
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