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Updated: Feb 13, 2026

Cargo Loading onto Kinesin Powered Molecular Shuttles
Published on: November 3, 2010
Ubiquilin 2: Shuttling Clients Out of Phase?
Ipsita Subudhi1, James Shorter1
1Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Abstract:
Ubiquilin 2 (UBQLN2) is an amyotrophic lateral sclerosis-linked molecular chaperone with a prion-like domain that directly engages ubiquitin to triage clients for proteasomal degradation. Dao et al. (2018) now establish that UBQLN2 forms ubiquitin-labile liquids, which may enable UBQLN2 to specifically extract ubiquitylated clients from stress granules for degradation.
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