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Updated: Feb 13, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Published on: August 21, 2019
Synergistic interactions promote behavior spreading and alter phase transitions on multiplex networks
Quan-Hui Liu1,2,3, Wei Wang1,2,4, Shi-Min Cai1,2,5
1Web Sciences Center, School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China.
Synergistic interactions in multiplex networks significantly boost behavior spreading. These interactions can alter phase transitions and create a unique two-stage spreading process, enhancing adoption across layers.
Area of Science:
- Complex Networks
- Sociophysics
- Computational Social Science
Background:
- Synergistic interactions enhance spreading in single-layer networks, sometimes causing explosive contagion.
- Behavior spreading dynamics on multiplex (multi-layered) networks are of growing research interest.
Purpose of the Study:
- To investigate the role of synergistic interactions in behavior spreading on double-layer networks.
- To model how adopting a behavior in one layer influences adoption in another layer.
Main Methods:
- Developed a synergistic behavior spreading model on a double-layer network.
- Employed edge-based compartmental theory and bifurcation analysis.
- Focused on the weak synergistic interaction regime with negligible dynamical correlation between layers.
Main Results:
- Synergistic interactions substantially enhance behavior spreading across both network layers.
- Interactions can shift the nature of phase transitions from continuous (second-order) to discontinuous (first-order).
- Observed a novel two-stage spreading process driven by synergistic effects.
Conclusions:
- Synergy is a key factor in promoting social behavior spreading on multiplex networks.
- The interplay between layers, mediated by synergy, fundamentally impacts spreading dynamics and transition behaviors.
- The findings provide a deeper understanding of complex contagion phenomena in interconnected systems.
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