Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

The Sense of Self: Reflected Self-Appraisal and Social Comparison

56.2K
According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.2K
Introduction to Special Senses01:26

Introduction to Special Senses

7.7K
Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
7.7K
Interdisciplinary Care: The Health Care Team-I01:21

Interdisciplinary Care: The Health Care Team-I

2.8K
An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care.
Physicians
The physician's primary responsibility is to diagnose illness and direct the medical or surgical treatment of the condition. The authority to admit patients to a healthcare agency or institution and practice care within that setting is granted to physicians by the healthcare agency or institution...
2.8K
Interdisciplinary Care: The Health Care Team-II01:18

Interdisciplinary Care: The Health Care Team-II

2.3K
An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care. Here are a few more healthcare professionals.
Physical Therapist
A physical therapist (PT) aims to restore function or prevent additional impairment in a patient following an injury or disease. Massage, heat, cold, water, sonar waves, exercises, and electrical stimulation are some treatments used by PTs to treat...
2.3K
Frequency-dependent Selection01:21

Frequency-dependent Selection

24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K
Tactile and Chemical Senses01:27

Tactile and Chemical Senses

826
Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex.
826

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insights and challenges on animal models for progressive multiple sclerosis.

Journal of neuroinflammation·2026
Same author

Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans.

The Journal of experimental medicine·2025
Same author

STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor.

Nature immunology·2025
Same author

STING and Nonnecroptotic MLKL-Mediated Mechanisms Improve Dendritic Cell Maturation and Killing of Cancer Cells.

European journal of immunology·2025
Same author

Corrigendum: Characterization of TLR9 responsiveness in cell subsets derived from <i>in vitro</i> pDC differentiation of hematopoietic stem and progenitor cells.

Frontiers in immunology·2025
Same author

Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction.

The Journal of biological chemistry·2025

Related Experiment Video

Updated: Feb 13, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
08:11

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

9.2K

STING dependent sensing - Does HIV actually care?

Christian Krapp1, Kasper Jønsson1, Martin R Jakobsen1

  • 1Department of Biomedicine, Faculty of Health, Aarhus University, Denmark.

Cytokine & Growth Factor Reviews
|March 18, 2018
PubMed
Summary

The STING pathway, crucial for innate immune DNA sensing, involves cGAS, IFI16, TBK1, and IRF3. This review explores its role in HIV pathogenesis and infection.

Keywords:
HIVIFI16Innate sensingSTING

More Related Videos

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

18.4K
Specific Marking of HIV-1 Positive Cells using a Rev-dependent Lentiviral Vector Expressing the Green Fluorescent Protein
09:53

Specific Marking of HIV-1 Positive Cells using a Rev-dependent Lentiviral Vector Expressing the Green Fluorescent Protein

Published on: September 23, 2010

13.4K

Related Experiment Videos

Last Updated: Feb 13, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
08:11

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

9.2K
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

18.4K
Specific Marking of HIV-1 Positive Cells using a Rev-dependent Lentiviral Vector Expressing the Green Fluorescent Protein
09:53

Specific Marking of HIV-1 Positive Cells using a Rev-dependent Lentiviral Vector Expressing the Green Fluorescent Protein

Published on: September 23, 2010

13.4K

Area of Science:

  • Immunology
  • Molecular Biology
  • Virology

Background:

  • The innate immune system detects threats via DNA sensing.
  • The STimulator of INterferon Genes (STING) pathway is central to this conserved mammalian mechanism.
  • STING is a highly regulated adaptor protein involved in a complex signaling network including cGAS, IFI16, TBK1, and IRF3.

Purpose of the Study:

  • To provide a comprehensive review of the STING pathway.
  • To detail the components and regulations of the STING pathway.
  • To investigate the potential role of STING-mediated DNA sensing in HIV pathogenesis.

Main Methods:

  • Literature review of current research on the STING pathway.
  • Analysis of STING pathway components and their interactions.
  • Examination of existing data linking DNA sensing to HIV infection.

Main Results:

  • The STING pathway is a key component of innate immunity, sensing cytosolic DNA from pathogens or damage.
  • The pathway involves sensors like cGAS and IFI16, and signaling molecules including TBK1 and IRF3.
  • The DNA sensing machinery, including STING, has been implicated in various diseases, including HIV.

Conclusions:

  • The STING pathway's role in HIV pathogenesis requires further comprehensive investigation.
  • Understanding STING regulation in the context of HIV may reveal new therapeutic targets.
  • This review consolidates current knowledge to address the question of STING's involvement in HIV infections.